Migraine and hormones

Migraine can be triggered by hormone fluctuations. These attacks happen more often and last longer than other types of migraine. They are also more severe and harder to treat. But it’s good to know there are different treatment options available.
Print / PDF

What is hormonal migraine?

For some women, hormone changes can trigger migraine. For example:

  • at puberty
  • during periods
  • around the time of menopause
  • with health conditions such as endometriosis.

More research is needed to better understand why this happens.

Hormonal migraine can be more intense and last longer than other types of migraine.

Why hormonal migraine matters

In Australia, about 70% of people with migraine are women. Migraine is an important women’s health issue as symptoms can impact many aspects of life, including work, relationships, social lives and health.

Migraine and puberty

After puberty, far more females experience migraine than males. This could be due to the oestrogen hormone.
Research suggests that:

  • hormonal changes during puberty can cause migraine in girls
  • migraine with aura is more common in young women after puberty
  • migraine with brainstem aura is most often diagnosed in adolescent girls.

Many girls have irregular periods at puberty, so it’s hard to know if migraine attacks and periods are linked.

Migraine with heavy and painful periods

Recent research suggests that hormone-like chemicals in the body called prostaglandins play an important role in female migraine.

Women with heavy or painful periods have higher levels of prostaglandins, which can create chronic pain and a higher sensitivity to pain.

If you have heavy or painful periods, you may be more likely to have menstrually-related migraine.

Migraine and endometriosis

More research is needed to better understand the link between migraine and endometriosis.

We do know that:

  • endometriosis can cause heavy and painful bleeding
  • women with endometriosis are thought to produce more prostaglandins
  • many women with endometriosis report having menstrual headaches
  • many migraine patients report a history of heavy and painful periods
  • starting periods early is a risk factor for migraine and endometriosis
  • women with migraine are up to 5 times more likely to have severe endometriosis.

Migraine and irregular periods

When oestrogen hormone levels drop during your menstrual cycle, it can trigger migraine attack. This can also happen when you have irregular periods.

You may have irregular periods at different times in your life, including the lead-up to menopause.

Other health issues, such as PCOS and underactive thyroid, can also cause irregular periods.

When periods are irregular, it can be hard to predict and manage migraine attacks.

Migraine and hormone medicines

Depending on your situation, hormone medicines may help you manage symptoms of hormonal migraine.

Hormone medicines can also affect migraine. So, if you need to use the Pill or menopausal hormone therapy (MHT), or undergo IVF, it’s important to find a treatment plan that works for you.

Migraine and menopausal hormone therapy (MHT)

If you have migraine and symptoms of menopause, ask your doctor about using menopausal hormone therapy (MHT).

Everyone’s experience of MHT is different. It may improve or worsen your migraine symptoms, or you may not notice any changes.

When you see your doctor, they will ask about your medical history, your experience of migraine and other risk factors to work out the best MHT treatment.

Your doctor will recommend a treatment that keeps your hormone levels as steady as possible, to reduce the risk of migraine attacks.

Depending on your situation, they may recommend different types of MHT, including patches, pills or implants under the skin. They will also consider which doses may work best for you.

If you haven’t had a hysterectomy, you’ll need combined oestrogen and progesterone therapy to reduce the risk of endometrial cancer (cancer of the uterus).

An IUD with lower progestin (a synthetic type of progesterone) may be a good option if progestin triggers migraine attacks.

Migraine and other hormone medicines

Ask your doctor about benefits and risks of taking hormone medicines for things like fertility treatment, health conditions like endometriosis or gender-affirming therapy. If you try a new hormone medicine and notice changes in your migraine patterns, see your doctor.

When to see your doctor about hormonal migraine

If you have hormonal migraine, don’t push through the pain. See your doctor and work on a treatment plan together.

Health information in your language