In June 2010, the US-based Endocrine Society issued a review of all the current evidence regarding the safety, benefits and risks of hormone replacement therapy (HRT).

In 2002, the Women's Health Initiative (WHI) study found that one form of HRT was associated with a small increase (less than 1 extra case per 1000 women per year) in the risk of heart disease and breast cancer in postmenopausal women.

However, the risks and benefits of HRT were not well explained to the general public and as a result, many women have stopped using traditional HRT.  

According to the Endocrine Society, research shows that younger women (50-59) who have only recently had their menopause respond differently to HRT than those who took part in the original study (average age 63). Younger women using HRT for five years experienced a 30-40 per cent decrease in mortality, no increased risk of heart disease and 90 per cent reduction of menopausal symptoms such as hot flushes or overactive bladder.

Jean Hailes endocrinologist Professor Henry Burger, one of the authors of the review, commented, "The Endocrine Society statement places use of HRT in a balanced perspective. When used for women who have recently experienced menopause and whose symptoms impact on their quality of life, HRT is safe and effective. It is the treatment of choice for hot flushes, night sweats and uncomfortable intercourse due to vaginal dryness."

Content Updated November 2010