Comments from researchers at the Jean Hailes Foundation for Women's Health - September 21, 2009
Study summary
Research based on the original Women's Health Initiative (WHI) study has just been published in the Lancet 2009; September 20, entitled "Oestrogen plus progestin and lung cancer in postmenopausal women (Women's Health Initiative trial): a post-hoc analysis of a randomised controlled trial. This research has noted that among women aged 60 years and over, there is a small increased risk of death from one type of lung cancer, (5 additional deaths per 10,000 women over 60 started on HRT per year) but no increased risk of death overall for women taking HRT compared to those not on HRT. The study did not show an increased number or rate of lung cancers. Importantly, these observations were not noted in women 50-59 years of age who make up the large majority of women starting HRT for menopausal symptom relief in Australia. In women over 60 years who are at high risk of lung cancer (ex or current smokers), this should be taken into account when weighing up the risks and benefits of beginning HRT, an uncommon practice in that age group.
The International Menopause Society, at their latest Congress, confirmed that for women aged 50 to 59, HRT remains the first line and most effective treatment for menopausal symptoms. For women in this age group there is no significant increase in risk in using HRT - in fact the benefits outweigh the risks. This recent study data does not influence that conclusion with no observed impact on women aged 50-59 years.