Dr Marie Misso is a Senior Evidence Officer with a background in basic research and translating research into practice and policy. Her PhD investigated the molecular mechanisms of metabolic disease and their relationship with estrogen, using mouse and human models. Moving fields, she has gained expertise in research methodology and synthesis of evidence through preparing systematic reviews for various state and federal agencies, supporting federal health policy makers to use evidence in their decision making, and teaching evidence based clinical practice to 2nd and 3rd year medical students and post-graduate students. She is highly experienced in developing evidence based guidelines, having played a key role in guidelines for osteoarthritis, cardiovascular disease and polycystic ovary syndrome and advising on the development of evidence based guidelines in the areas of antenatal care and problem gambling. She is an active member of the NHMRC Guideline Network and has contributed to the 2011 NMHRC standard for clinical practice guidelines.

Publications

Teede HJ, Misso ML, Deeks A, Wong J, Moran LJ, Stuckey B, Norman RJ, Costello MF. 2011 Assessment and management of polycystic ovary syndrome: summary of an evidence based guideline. Med J Australia In press

Ilic D, Tepper K, Misso M. 2011 Teaching evidence based medicine literature searching skills to medical students during the clinical years - a protocol for a randomised controlled trial. BMC Medical Education, 11:49

Ilic D, Misso ML. 2011 Screening for testicular cancer. (Review) Cochrane Database of Systematic Reviews, Issue 2.

Moran LJ, Misso ML, Wild RA, Norman RJ. 2010 Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction Update, July-August 2010; 16: 347 - 363.

Misso ML, Egberts KJ, Page M, O’Connor D, Shaw J.  2010 Continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes mellitus. (Review) Cochrane Database of Systematic Reviews. Issue 1 (Jan), 2010.
- The full review, a summary and a commentary was reprinted in Evidence Based Child Health 5: 1726–1872. Also available as an audio podcast

Misso ML, Shaw J, Egberts KJ, O’Connor D, Page M.  2010 Invited response to commentary on: Continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes mellitus. Evidence-Based Child Health: A Cochrane Review Journal 5: 1870–1872.

Misso ML, Pitt V, Jones K, Barnes H, Piterman L, Green S. 2008 Quality and consistency of clinical practice guidelines for diagnosis and management of osteoarthritis of the hip and knee: a descriptive overview of published guidelines. Med J Australia 189: 394–399.

Turner T, Misso ML, Harris C & Green S. 2008 Development of evidence-based clinical practice guidelines (CPGs): comparing approaches.  Implementation Science 3:45.

Misso ML, Jang C, Adams J, Tran J, Murata Y, Bell R, Boon WC, Simpson ER & Davis SR. 2005 Differential expression of factors involved in adipose tissue metabolism with age and the menopause transition.  Maturitas.  51:299-306.

Misso ML, Jang C, Adams J, Tran J, Murata Y, Bell R, Boon WC, Simpson ER & Davis SR. 2005 Adipose aromatase gene expression is greater in older women and is unaffected by postmenopausal estrogen therapy.  Menopause.  12(2):210-215. ***Australasian Menopause Society Scientific Prize for 2004 awarded for this paper

Misso ML, Hewitt KN, Boon WC, Murata Y, Jones MEE & Simpson ER. 2005 Cholesterol feeding prevents adiposity in the obese female aromatase knockout (ArKO) mouse.  Hormone and Metabolic Research.  37:26-31.

Simpson ER, Misso M, Hewitt KN, Hill RA, Boon WC, Jones ME, Kovacic A, Zhou J, Clyne CD. 2005 Estrogen - the good, the bad, and the unexpected.  Endocrine Reviews. 26(3):322-30.

Simpson E, Jones M, Misso M, Hewitt K, Hill R, Maffei L, Carani C, Boon WC. 2005 Estrogen, a fundamental player in energy homeostasis. J. Steroid Biochem. Mol. Biol. 95:3-8.

Britt KL, Saunders PK, McPherson SJ, Misso ML, Simpson ER, Findlay JK.  2004  Estrogen actions on follicle formation and early follicle development.  Biol Reprod. Nov;71(5):1712-23.

Britt KL, Stanton PG, Misso M, Simpson ER, Findlay JK. 2004 The effects of estrogen on the expression of genes underlying the differentiation of somatic cells in the murine gonad.  Endocrinology. 145(8):3950-60.

Jones MEE, Thorburn AW, Britt KL, Hewitt KN, Misso ML, Wreford NG, Proietto J, Oz O, Leury B, Robertson K, Yao S & Simpson ER. 2003 Aromatase-deficient (ArKO) mice have a phenotype of  increased adiposity.  Progress in Obesity Research Chapter 180 pp 852-856. Medeiros-Neto G, Halpern A & Bouchard (eds).

Misso ML, Murata Y, Boon WC, Jones MEE, Britt KL & Simpson ER. 2003 Cellular and molecular characterisation of the adipose phenotype of the aromatase-deficient mouse. Endocrinology. 144(4):1474-80.

Jones MEE, Thorburn AW, Britt KL, Hewitt KN, Misso ML, Wreford NG, Proietto J, Oz O, Leury B, Robertson K, Yao S and Simpson ER. 2001 Aromatase-deficient (ArKO) mice accumulate excess adipose tissue.  J. Steroid Biochem. Mol. Biol.  79(1-5): 3-9.

Kraniou Y, Cameron-Smith D, Misso ML, Collier G & Hargreaves M.  2000 Effects of exercise on GLUT4 and glycogenin gene expression in human skeletal muscle.  Journal of AppliedPhysiology. 88(2):794-796.

Jean Hailes Foundation for Women’s Health. Evidence based guideline for the assessment and management of polycystic ovary syndrome. 2010 - current. NHMRC approved, translation component ongoing

Role: Systematic reviewer and guideline developer

Problem Gambling Treatment and Research Centre. Evidence based guidelines for screening, assessment and management of problem gambling. 2009 – March 2011. NHMRC approved

Role: Expert advisor for systematic review and guideline development methodology

Participated in the consultation exercise during the first stage of a DoHA funded project to outline the components of a collaborative model for CVD guideline development in Australia.

Role: Participated in the consultation process that used the Delphi Technique

Evidence report commissioned by the Sports Industry Section, DoHA: Effects of water familiarity on development, drowning and water-based injuries.

Role: Systematic reviewer

Antenatal care guidelines. 2009.

Role: Expert advisor for systematic review and guideline development methodology (NHMRC GAR representative)

NHMRC. Guidelines for developing guidelines supplement. 2010.

Role: Contributed (by request) methodological advice to NHMRC’s guidance for evidence–based clinical practice guideline developers

Centre for Clinical Effectiveness (CCE) Evidence Service for Transport Accident Commission and Worksafe Victoria 1) Radiofrequency denervation evidence report 2) Spinal injections evidence report

Role: Systematic reviewer

National Vascular Disease Prevention Alliance. Guidelines for the assessment of absolute cardiovascular disease risk. 2009. NHMRC approved.

Role: Systematic reviewer and guideline developer.

Content updated 23 August 2011