"A major misperception concerning postmenopausal hormone replacement therapy (HRT) is that the associated risks are large in magnitude and unique to HRT", say Drs Howard Hodis and Wendy Mack in the second part of a two-part review of HRT and prevention of coronary heart disease, published online in May 2013 by the Journal of the American Geriatrics Society.
In part 1, the authors compared data on the effects of aspirin, statins and HRT on coronary heart disease risk - Neither aspirin nor statins were found to be effective in a "primary prevention" setting in women, but starting HRT before age 60 significantly reduced both disease risk and mortality.
In the second article, the authors review safety data from randomised controlled trials, concluding that the risks of HRT are "predominantly rare" (less than 1 event per 1,000 women treated) and it can be used safely for primary coronary heart disease prevention in women under 60 years old or less than 10 years past menopause.
This article was posted in International Research
and tagged with HRT